Hauv kev tshawb nrhiav thoob ntiaj teb rau cov khoom sib txuas tshiab los tiv thaiv kev mob qog noj ntshav thiab kev kho mob tsis zoo, Hloov Kho Citrus Pectin (MCP) tau hloov los ntawm kev noj zaub mov ntxiv mus rau tus neeg sib tw tseem ceeb rau kev kho tshuaj - qib adjuvant therapy. Rau oncology- tsom rau cov tuam txhab tshuaj, qhov kev sib tw tseem ceeb tsis yog tsuas yog tua cov qog nqaij hlav xwb, tab sis kev tswj cov kab mob metastasis thiab kov yeej ntau- tshuaj tiv thaiv (MDR). Qhov no yog qhov twgzoo tshaj hloov citrus pectin-tus yam ntxwv los ntawm qhov hnyav molecular thiab cov ntsiab lus galactosyl siab- dhau los ua cov cuab yeej cuab tam tseem ceeb.
Cov txheej txheem kho mob ntawm MCP nyob rau hauv nws lub luag hauj lwm raws li ib tug natural antagonist rau Galectin-3 (Gal-3). Gal-3 yog 31 $ kDa$ multifunctional oncogenic protein uas tswj cov cell adhesion, proliferation, thiab angiogenesis. Thaum overexpressed, nws tsim ib qho kev tiv thaiv "cov ntaub thaiv npog" nyob ib ncig ntawm cov qog nqaij hlav cancer, pab txhawb lawv txoj sia nyob hauv cov hlab ntsha thiab lawv qhov kawg colonization hauv cov kab mob nyob deb xws li lub ntsws lossis daim siab. Kev tshawb fawb tau pom tias MCP, tshwj xeeb tshaj yog nplua nuj nyob rau hauv $\\beta$-galactose units, khi rau cov carbohydrate-paub qhov chaw ntawm Galectin-3, zoo thaiv nws lub peev xwm los txhawb qog aggregation thiab metastasis.
Tsis tas li ntawd, rau cov kws tsim tshuaj, kev sib koom ua ke ntawm MCP thiab cov khoom siv tshuaj khomob yog qhov tseem ceeb tshaj plaws. Cov kev tshawb fawb tau ua nrog Gold Kropn's MCP tau pom tias nws tuaj yeem txhim kho qhov rhiab heev ntawm cov qog nqaij hlav cancer-xws li MDA-MB-231 kab mob qog noj ntshav mis- rau cov tshuaj xws li 5-Fluorouracil (5-FU), cisplatin, thiab taxol. Los ntawm inhibiting lub anti-apoptotic signals kho los ntawm Galectin-3, MCP tso cai rau txo qis npaum li cas ntawm cov tshuaj lom chemotherapy kom siv tau zoo dua, yog li txo cov kev mob tshwm sim thiab txhim kho cov neeg mob lub neej zoo.
Zhejiang Kub Kropn Biotechnology Co., Ltd. yog lub teb chaws siab - thev naus laus zis kev lag luam uas tau tsim nws lub koob npe nrov ntawm lub hauv paus ntsiab lus ntawm kev tshawb fawb nruj heev. Los ntawm kev koom tes nrog cov tsev kho mob loj xws li Fudan University thiab Zhejiang University, lawv tau ua kom zoo dua lawv cov khoom tsim los tsim kom muaj kev ntseeg siab tiag tiag, tshawb fawb-qib MCP. Lawv cov txheej txheem pib nrog siab -cov txiv qaub uas muaj txiaj ntsig zoo, qhov zoo tshaj pectin. Tom qab ntawd lawv siv cov txheej txheem enzymatic hydrolysis siab heev-txoj kev huv, meej- kom ntseeg tau tias lawv MCP muaj pes tsawg molecular hnyav thiab cov qauv tsim nyog rau kev nqus dej. Tag nrho cov txheej txheem no muaj kev tiv thaiv nyob rau hauv 100,000-qib GMP-certified facility, lav lub purity thiab potency xav tau rau ib yam khoom uas koj yuav ntseeg tau nrog koj noj qab haus huv. Qhov kev cog lus rau kev ua tau zoo no ua kom ntseeg tau tias MCP tsis yog ib qho ntxiv, tab sis yog ib qho cuab yeej txhim khu kev qha rau kev txhawb nqa koj lub cev tiv thaiv kab mob thiab fibrosis.
Raws li tus thawj cojhloov citrus pectin tsum, Kub Kropn muab cov khoom lag luam ua tau raws li cov qauv nruj ntawm kev lag luam kws tshuaj. Nrog rau cov zis txhua xyoo ntawm 120 tons thiab purity profile qhia galacturonic acid qib siab li 96.05%, peb tau nruab los txhawb nqa loj - teev kev kho mob thiab kev tsim tshuaj.
Yog xav paub ntxiv txog qhov kev tshawb fawb no - txhawb nqa ntxiv, thov hu rau wilson@zjgykp.com.