Hloov kho Citrus Pectin hauv Kev sim qauv ntawm qog loj hlob, Angiogenesis, thiab Metastasis
Ib lub vev xaib qub-npaj cov ntsiab lus ntawm kev tshawb fawb ua ntej tau luam tawm hauv Phau Ntawv Xov Xwm ntawm Lub Tsev Haujlwm Saib Xyuas Cancer National.
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Tshaj tawm |
Nangia-Maker P, et al. Phau ntawv Journal ntawm National Cancer Institute . 2002; 94(24): 1854-1862. |
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Hom kev kawm |
Hauv -kev sim vitro thiab tib neeg qog nqaij hlav-cov kev tshawb fawb ntawm tes xenograft hauv cov nas liab qab. |
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Kev tshawb fawb tsom |
Tej yam tshwm sim ntawm MCP ntawm galectin -3-txog cell adhesion, qog-associated angiogenesis, thiab kev sim metastasis. |
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Pov thawj ciam teb |
Cov pov thawj preclinical nkaus xwb. Cov kev tshawb pom no tsis qhia txog kev tiv thaiv, kev kho mob, lossis kev kho mob qog noj ntshav hauv tib neeg. |
Kev Tshawb Fawb Txog Kev Tshawb Fawb
Txoj kev tshawb no tshawb fawb seb puas tau hloov citrus pectin (MCP), ib qho dej -soluble pectin derivative nrog qis dua -molecular- qauv hnyav dua li cov citrus pectin, tuaj yeem cuam tshuam cov txheej txheem lom neeg txuas nrog cov qog nqaij hlav hauv kev sim. Kev ua haujlwm tau tsom mus rau galectin-3, carbohydrate-binding protein cuam tshuam nrog kev lees paub ntawm tes, cell adhesion, thiab kev ua haujlwm ntsig txog angiogenesis.
Cov kws tshawb fawb tau muab piv rau MCP nrog cov citrus pectin uas tsis tau hloov kho thiab tshuaj xyuas nws cov teebmeem hauv endothelial- kev soj ntsuam ntawm tes thiab hauv cov nas liab qab cog nrog tib neeg lub mis lossis cov qog nqaij hlav qog noj ntshav. MCP tau muab qhov ncauj rau cov nas los ntawm cov dej haus thaum lub sijhawm sim.
Cov kev tshawb fawb tseem ceeb
- Kev sim qog cov qauv.Hauv cov duab liab qab-cov qauv nas siv hauv qhov kev tshawb fawb no, MCP- cov pab pawg noj zaub tau pom cov qog loj hlob qeeb thiab pom cov kab mob metastatic tsawg dua li pawg tswj hwm. Cov kev soj ntsuam no koom nrog tib neeg lub mis thiab cov kab mob qog noj ntshav hauv cov kab mob qog nqaij hlav hauv cov tsiaj.
- Cov qog nqaij hlav-cov ntshav sib txuas- lub nkoj tsim.Cov qog nqaij hlav los ntawm MCP-cov nas noj tau qis dua ntsuas cov ntshav-vsel ntom. Hauv kab lis kev cai tib neeg cov kab mob endothelial, MCP kuj txo qhov tsim ntawm capillary -zoo li cov qauv hauv kev sib xyaw ua ke- nyob ntawm qhov chaw sim.
- Cell migration thiab adhesion.Hauv vitro, MCP txo cov galectin-3-txuas nrog endothelial-cell migration thiab cuam tshuam nrog kev khi ntawm galectin-3 thiab endothelial hlwb. Nws kuj txo qis adhesion ntawm galectin-3-qhia cov qog nqaij hlav cancer mis thiab cov hlwb endothelial.
- Muaj kev cuam tshuam txog kev lom neeg.Cov kws sau ntawv tau hais tias MCP tuaj yeem cuam tshuam rau cov carbohydrate- cov xwm txheej sib tham nrog cov galectin-3. Cov xwm txheej zoo li no cuam tshuam rau kev sim ua qauv ntawm cell adhesion, angiogenesis, thiab metastatic kis.
Yuav txhais li cas Kev Tshawb Fawb no
Cov ntawv tshaj tawm no muab cov pov thawj kev siv tshuab thiab cov ntaub ntawv pov thawj rau kev tshawb fawb ntxiv ntawm MCP. Txoj kev tshawb no tau ua nyob rau hauv cell-raws li systems thiab immunodeficient nas qauv, tsis nyob rau hauv tib neeg cov neeg koom nrog. Cov txiaj ntsig los ntawm cov qauv no tsis tuaj yeem txhais ncaj qha rau hauv cov txiaj ntsig kev noj qab haus huv hauv tib neeg.
Lub luag haujlwm kev sib txuas lus ceeb toom:Qhov kev tshawb fawb no yuav tsum tsis txhob muab txhais ua pov thawj tias MCP tiv thaiv, kho, lossis kho mob qog noj ntshav. Tib neeg cov kev tshawb fawb soj ntsuam yog xav tau los ntsuam xyuas qhov tseeb ntawm qhov chaw kho mob, kev siv tsim nyog, ntau npaum li cas, thiab kev nyab xeeb hauv cov neeg tshwj xeeb.
Kev Tshaj Tawm Thawj
Nangia-Makker P, Hogan V, Honjo Y, Baccarini S, Tait L, Bresalier R, Raz A. Inhibition of Human Cancer Cell Growth and Metastasis in Nude Mice by Oral Intake of Modified Citrus Pectin. Phau ntawv Journal ntawm National Cancer Institute. 2002; 94(24): 1854-1862.
Thov Daim Ntawv Tshawb Fawb Tag Nrho
Hu rau peb kom thov kom tiav cov ntawv tshaj tawm thiab sib tham txog Hloov Kho Citrus Pectin cov khoom xyaw tshwj xeeb thiab cov ntaub ntawv thov.